The Anti-Angiogenic Effects of Anti-Human Immunodeficiency Virus Drugs

construction of pseudotyped human immunodeficiency virus for evaluation of anti-hiv drugs

Sales for anti-angiogenic drugs

In 1971, Judah Folkman developed the concept of “anti-angiogenesis” as a potential treatment of cancer due to “the prevention of new vessel sprouts from penetrating into early tumor implant” [1]. Beginning in the 1980’s, the industry exploited the field of anti-angiogenesis for creating new therapeutic molecules in angiogenesisdependent diseases. In 2004, the first anti-angiogenic drug, bevaciz...

Current antiretroviral drugs for human immunodeficiency virus infection: review article

Currently, there are about 37 million people worldwide living with human immunodeficiency virus (HIV) /AIDS, with an estimated two million new cases per year globally. According to estimates from the World Health Organization (WHO), only 75% of the population with HIV know their status. Initially, HIV infection was associated with significantly increased rates of mortality and morbidity. Howeve...

Anti-Angiogenic Therapeutic Drugs for Treatment of Human Cancer

One of the proposed benefits of targeted therapies is reduced toxicity and improved quality of life. The approval of a new broad family of molecularly targeted anticancer drugs represents one of the most significant recent advances in clinical oncology. The growth of solid tumors is dependent on their capacity to acquire a blood supply. Much effort has been directed towards the development of d...

Anti-Angiogenic and Anti-Proliferative Effects of Physalis Alkekengi Hydroalcholic Extract on Breast Cancer in Mice

Background & Objective: The Physalis alkekengi is a herbaceous plant belonging to Solanaceae family. According to research, this plant can help inhibit cancer cell growth. Materials & Methods: In this study, the extract of Physalis alkekengi was used to suppress angiogenesis in Balb/c mice. First, the MC4L2 cells were injected in the mice breastbone and the tumor began to grow in this area, th...